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KMID : 0895420090190020127
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Journal of Korean Society of Occupational and Enviromental Hygiene
2009 Volume.19 No. 2 p.127 ~ p.138
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Domestic Rock Wool Toxicity Study on Respiratory System and Biopersistence Evaluation in Sprague-Dawely Rats
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Chung Yong-Hyun
Han Jeong-Hee
Kang Min-Goo
Lee Sung-Bae
Kim Hyun-Young
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Abstract
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Rock wool, a kind of asbestos substitutes, was analyzed for its physicochemical properties. After fivers of rock wool were instilled into rat lungs, These pathological changes were evaluated. In addition, the fibers in the lungs were counted and characterized after the lungs were treated for electron microscopical analysis. The lungs of rats showed pathological lesions such as granulomatous changes, but these lesions disappeared at 28 days groups after instilled rats. The rock wool fibers in the lungs decreased more 50 % after 28 days instilled into rat lungs. And rock wool showed early change in fiber compositions after 3 days compare with chrysotile showed after 7 days instilled into rat lungs. This study showed that the durability of rock wool in the lungs is more milder than chrysotile.
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KEYWORD
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Rock wool, rat, biopersistence, intratracheal instillation, TEM-EDS
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